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Get To Know AYVAKIT^® (avapritinib)

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In-person at

During the Get To Know AYVAKIT event presented by Blueprint Medicines, a healthcare professional speaker with experience in indolent systemic mastocytosis (ISM) will present educational information about AYVAKIT for adults with ISM: the clinical trial, how to take AYVAKIT and potential side effects. They will also cover important topics to discuss with your doctor to help determine if AYVAKIT may be right for you, and a person living with ISM will share their individual experience with AYVAKIT. Don’t miss out on learning about how this treatment may help reduce symptoms of ISM.

Blueprint Medicines' educational events are promotional programs and do not provide medical advice. Speakers are compensated to share information on behalf of Blueprint Medicines and not to provide medical guidance. Always consult with your doctor for medical advice.

Presented by:

Honor Hightshue

Family Nurse Practitioner

Janiel

AYVAKIT Patient

At Blueprint Medicines, we deeply value creating environments that foster learning and meaningful connections. To achieve this, our programs are hosted in private rooms in restaurants or hotel conference rooms.

We understand and acknowledge that as a person living with SM, you might face certain environmental sensitivities, triggers. While these venues are private, they are also part of public spaces where various environmental factors could be present. We wish to be transparent and let you know that we cannot fully guarantee an environment free of potential triggers related to SM.

Your health and comfort are paramount to us, and we encourage you to make an informed decision regarding your attendance. Consulting with your healthcare team could provide additional guidance.

Additionally, in our commitment to creating an accommodating atmosphere for the program attendees, we kindly request that all attendees refrain from wearing fragranced products the day of the program.

We hope this information is helpful as you prepare to attend the AYVAKIT Informational program while registering on this page.

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INDICATION

WHAT IS AYVAKIT^® (avapritinib)?

AYVAKIT^® (avapritinib) is a prescription medicine used to treat adults with indolent systemic mastocytosis (ISM). AYVAKIT is not recommended in people with low platelet counts (less than 50 X 10⁹/L).

It is not known if AYVAKIT is safe and effective in children.

IMPORTANT SAFETY INFORMATION

AYVAKIT^® (avapritinib) may cause serious side effects, including:

Bleeding in your brain. Serious bleeding in the brain may happen during treatment with AYVAKIT and may lead to death. Stop taking AYVAKIT and tell your healthcare provider right away if you develop any symptoms such as severe headache, nausea, vomiting, vision changes, drowsiness, dizziness, confusion, or severe weakness on one or more side of your body. Bleeding in the brain has not been seen in people treated with AYVAKIT for ISM.

Cognitive effects. Cognitive side effects can happen during treatment with AYVAKIT and can be severe. Tell your healthcare provider if you develop any new or worsening cognitive symptoms including forgetfulness, confusion, getting lost, trouble thinking, drowsiness, trouble staying awake (somnolence), word finding problems, seeing objects or hearing things that are not there (hallucinations), or a change in mood or behavior.

Skin sensitivity to sunlight (photosensitivity). Your skin may be sensitive to the sun or other forms of light (photosensitivity) during treatment with AYVAKIT. Avoid or limit exposure to direct sunlight, sunlamps, and other sources of ultraviolet radiation during treatment and for 1 week after stopping treatment with AYVAKIT. Use sunscreen or wear clothes that cover your skin if you need to be out in the sun.

Before taking AYVAKIT, tell your healthcare provider about all of your medical conditions, including if you:

have a history of bulging or weakening of a blood vessel wall (aneurysm) or bleeding in your brain
have a history of stroke within the last year
have low platelet counts
have or have had liver problems
are pregnant or plan to become pregnant. AYVAKIT can cause harm to your unborn baby
Females who are able to become pregnant: Your healthcare provider should do a pregnancy test before you start AYVAKIT. You should use effective birth control (contraception) during treatment with AYVAKIT and for 6 weeks after the final dose of AYVAKIT. Talk to your healthcare provider about birth control methods that may be right for you. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with AYVAKIT.
Males with female partners who are able to become pregnant should use effective birth control (contraception) during treatment and for 6 weeks after the final dose of AYVAKIT.
are breastfeeding or plan to breastfeed. It is not known if AYVAKIT passes into your breast milk. Do not breastfeed during treatment with AYVAKIT and for at least 2 weeks after the final dose of AYVAKIT. Talk to your healthcare provider about the best way to feed your baby during this time

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. AYVAKIT may affect the way other medicines work, and certain other medicines may affect how AYVAKIT works. Especially tell your healthcare provider if you take medicines that prevent blood clots.

Do not drive or operate hazardous machinery if you have confusion or trouble thinking during treatment with AYVAKIT.

The most common side effects of AYVAKIT in people with ISM include: swelling around your eyes, dizziness, swelling of your arms and legs, and flushing.

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with AYVAKIT if you develop certain side effects. AYVAKIT may cause fertility problems in females and males. Talk to your healthcare provider if this is a concern for you.

These are not all of the possible side effects of AYVAKIT. Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see the full Prescribing Information and Patient Information for AYVAKIT.

IMPORTANT SAFETY INFORMATION

AYVAKIT^® (avapritinib) may cause serious side effects, including:

INDICATION

WHAT IS AYVAKIT^® (avapritinib)?

It is not known if AYVAKIT is safe and effective in children.

INDICATION & IMPORTANT SAFETY INFORMATION

AYVAKIT^® (avapritinib) may cause serious side effects, including:

Bleeding in your brain. Serious bleeding in the brain may happen during treatment with AYVAKIT and may lead to death. Stop taking

INDICATION

WHAT IS AYVAKIT^® (avapritinib)?

It is not known if AYVAKIT is safe and effective in children.

IMPORTANT SAFETY INFORMATION

AYVAKIT^® (avapritinib) may cause serious side effects, including:

Before taking AYVAKIT, tell your healthcare provider about all of your medical conditions, including if you:

have a history of bulging or weakening of a blood vessel wall (aneurysm) or bleeding in your brain
have a history of stroke within the last year
have low platelet counts
have or have had liver problems
are pregnant or plan to become pregnant. AYVAKIT can cause harm to your unborn baby
Females who are able to become pregnant: Your healthcare provider should do a pregnancy test before you start AYVAKIT. You should use effective birth control (contraception) during treatment with AYVAKIT and for 6 weeks after the final dose of AYVAKIT. Talk to your healthcare provider about birth control methods that may be right for you. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with AYVAKIT.
Males with female partners who are able to become pregnant should use effective birth control (contraception) during treatment and for 6 weeks after the final dose of AYVAKIT.
are breastfeeding or plan to breastfeed. It is not known if AYVAKIT passes into your breast milk. Do not breastfeed during treatment with AYVAKIT and for at least 2 weeks after the final dose of AYVAKIT. Talk to your healthcare provider about the best way to feed your baby during this time

Do not drive or operate hazardous machinery if you have confusion or trouble thinking during treatment with AYVAKIT.

The most common side effects of AYVAKIT in people with ISM include: swelling around your eyes, dizziness, swelling of your arms and legs, and flushing.

Please see the full Prescribing Information and Patient Information for AYVAKIT.

Get To Know AYVAKIT® (avapritinib)

Register for this event

Get To Know AYVAKIT^® (avapritinib)